| Wed 10/28 7:00 PM ET | @ Middle Tennessee Blue Raiders | -2.5 | Kennesaw State Owls |
| Wed 10/28 8:00 PM ET | Jacksonville State Gamecocks | -3.5 | @ New Mexico State Aggies |
| Thu 10/29 7:30 PM ET | @ James Madison Dukes | -20.5 | Troy Trojans |
| Thu 10/29 7:30 PM ET | @ North Texas Mean Green | -13.5 | Florida Atlantic Owls |
| Fri 10/30 7:00 PM ET | Tulane Green Wave | -10.5 | @ Charlotte 49ers |
| Fri 10/30 7:30 PM ET | @ UCF Knights | -1.5 | Baylor Bears |
| Fri 10/30 10:30 PM ET | Kent State Golden Flashes | -9.5 | @ Sacramento State Hornets |
| Sat 10/31 12:00 PM ET | SMU Mustangs | -10.0 | @ Syracuse Orange |
| Sat 10/31 12:00 PM ET | @ Texas Tech Red Raiders | -3.5 | Arizona Wildcats |
| Sat 10/31 12:00 PM ET | Illinois Fighting Illini | -2.5 | @ Maryland Terrapins |
| Sat 10/31 12:00 PM ET | @ South Florida Bulls | -8.5 | UAB Blazers |
| Sat 10/31 12:00 PM ET | @ Western Michigan Broncos | -13.5 | Bowling Green Falcons |
| Sat 10/31 12:00 PM ET | @ Iowa Hawkeyes | -3.5 | Wisconsin Badgers |
| Sat 10/31 12:00 PM ET | @ Duke Blue Devils | -7.0 | Boston College Eagles |
| Sat 10/31 12:00 PM ET | Notre Dame Fighting Irish | -30.0 | @ Navy Midshipmen |
| Sat 10/31 12:00 PM ET | @ North Carolina State Wolfpack | -7.0 | California Golden Bears |
| Sat 10/31 12:30 PM ET | Michigan Wolverines | -14.0 | @ Rutgers Scarlet Knights |
| Sat 10/31 12:45 PM ET | @ Mississippi Rebels | -13.0 | Auburn Tigers |
| Sat 10/31 1:00 PM ET | Marshall Thundering Herd | -2.5 | @ Old Dominion Monarchs |
| Sat 10/31 2:00 PM ET | @ Georgia State Panthers | -6.5 | Coastal Carolina Chanticleers |
| Sat 10/31 2:00 PM ET | Kansas State Wildcats | -2.5 | @ Colorado Buffaloes |
| Sat 10/31 3:00 PM ET | @ Air Force Falcons | -2.5 | UConn Huskies |
| Sat 10/31 3:00 PM ET | @ East Carolina Pirates | -6.0 | Temple Owls |
| Sat 10/31 3:00 PM ET | Louisiana Tech Bulldogs | -5.0 | @ South Alabama Jaguars |
| Sat 10/31 3:15 PM ET | @ Louisville Cardinals | -22.5 | Stanford Cardinal |
| Sat 10/31 3:30 PM ET | @ BYU Cougars | -16.5 | Arizona State Sun Devils |
| Sat 10/31 3:30 PM ET | @ Indiana Hoosiers | -20.0 | Minnesota Golden Gophers |
| Sat 10/31 3:30 PM ET | @ Oregon Ducks | -3.5 | Northwestern Wildcats |
| Sat 10/31 3:30 PM ET | @ TCU Horned Frogs | -6.0 | Kansas Jayhawks |
| Sat 10/31 3:30 PM ET | @ North Dakota State Bison | -24.5 | UTEP Miners |
| Sat 10/31 3:30 PM ET | @ Georgia Bulldogs | -11.5 | Florida Gators |
| Sat 10/31 3:30 PM ET | @ Utah State Aggies | -6.5 | Colorado State Rams |
| Sat 10/31 3:30 PM ET | @ Liberty Flames | -14.0 | Florida International Panthers |
| Sat 10/31 3:30 PM ET | Southern Miss Golden Eagles | -3.5 | @ Louisiana-Monroe Warhawks |
| Sat 10/31 3:45 PM ET | @ Wake Forest Demon Deacons | -12.5 | Virginia Cavaliers |
| Sat 10/31 3:45 PM ET | Utah Utes | -6.5 | @ Cincinnati Bearcats |
| Sat 10/31 4:00 PM ET | New Mexico Lobos | -14.5 | @ San Jose State Spartans |
| Sat 10/31 4:15 PM ET | @ Oklahoma Sooners | -5.0 | South Carolina Gamecocks |
| Sat 10/31 4:15 PM ET | @ UCLA Bruins | -22.5 | Nevada Wolf Pack |
| Sat 10/31 4:15 PM ET | @ Penn State Nittany Lions | -7.5 | Purdue Boilermakers |
| Sat 10/31 6:30 PM ET | @ Georgia Southern Eagles | -5.0 | Appalachian State Mountaineers |
| Sat 10/31 7:00 PM ET | @ Florida State Seminoles | -5.5 | Clemson Tigers |
| Sat 10/31 7:00 PM ET | Oklahoma State Cowboys | -8.5 | @ Iowa State Cyclones |
| Sat 10/31 7:00 PM ET | @ San Diego State Aztecs | -2.5 | Washington State Cougars |
| Sat 10/31 7:30 PM ET | Ohio State Buckeyes | -6.5 | @ USC Trojans |
| Sat 10/31 7:30 PM ET | @ Pittsburgh Panthers | -7.5 | Georgia Tech Yellow Jackets |
| Sat 10/31 7:30 PM ET | Miami (FL) Hurricanes | -14.5 | @ North Carolina Tar Heels |
| Sat 10/31 7:30 PM ET | @ Texas Longhorns | -20.5 | Mississippi State Bulldogs |
| Sat 10/31 7:45 PM ET | Missouri Tigers | -10.0 | @ Arkansas Razorbacks |
| Sat 10/31 8:00 PM ET | @ Nebraska Cornhuskers | -8.0 | Washington Huskies |
| Sat 10/31 8:00 PM ET | @ Memphis Tigers | -5.5 | Army Black Knights |
| Sat 10/31 10:00 PM ET | @ Boise State Broncos | -11.0 | Texas State Bobcats |
| Sat 10/31 10:30 PM ET | @ UNLV Rebels | -24.0 | Northern Illinois Huskies |
| Sat 10/31 11:00 PM ET | Oregon State Beavers | -5.5 | @ Fresno State Bulldogs |
| Sat 11/07 12:00 PM ET | Texas Longhorns | -5.5 | @ Missouri Tigers |
| Sat 11/07 12:00 PM ET | @ Utah Utes | -3.5 | BYU Cougars |
| Sat 11/07 3:30 PM ET | @ LSU Tigers | -3.5 | Alabama Crimson Tide |
| Sat 11/07 6:15 PM ET | @ Tennessee Volunteers | -5.5 | Kentucky Wildcats |
| Sat 11/07 7:30 PM ET | Georgia Bulldogs | -2.5 | @ Mississippi Rebels |
| Sat 11/07 7:30 PM ET | @ Notre Dame Fighting Irish | -3.5 | Miami (FL) Hurricanes |